Computational Methods For Predicting Protein–Protein Interactions
Identifieur interne : 002344 ( Main/Exploration ); précédent : 002343; suivant : 002345Computational Methods For Predicting Protein–Protein Interactions
Auteurs : Sylvain Pitre [Canada] ; Md Alamgir [Canada] ; James R. Green [Canada] ; Michel Dumontier [Canada] ; Frank Dehne [Canada] ; Ashkan Golshani [Canada]Source :
- Advances in Biochemical Engineering/Biotechnology [ 0724-6145 ] ; 2008.
Abstract
Abstract: Protein–protein interactions (PPIs) play a critical role in many cellular functions. A number of experimental techniques have been applied to discover PPIs; however, these techniques are expensive in terms of time, money, and expertise. There are also large discrepancies between the PPI data collected by the same or different techniques in the same organism. We therefore turn to computational techniques for the prediction of PPIs. Computational techniques have been applied to the collection, indexing, validation, analysis, and extrapolation of PPI data. This chapter will focus on computational prediction of PPI, reviewing a number of techniques including PIPE, developed in our own laboratory. For comparison, the conventional large-scale approaches to predict PPIs are also briefly discussed. The chapter concludes with a discussion of the limitations of both experimental and computational methods of determining PPIs.
Url:
DOI: 10.1007/10_2007_089
Affiliations:
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Green</name></author><author><name sortKey="Dumontier, Michel" sort="Dumontier, Michel" uniqKey="Dumontier M" first="Michel" last="Dumontier">Michel Dumontier</name></author><author><name sortKey="Dehne, Frank" sort="Dehne, Frank" uniqKey="Dehne F" first="Frank" last="Dehne">Frank Dehne</name></author><author><name sortKey="Golshani, Ashkan" sort="Golshani, Ashkan" uniqKey="Golshani A" first="Ashkan" last="Golshani">Ashkan Golshani</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:16255347B412D2FD5DB45D7BC462DEFA1DACF753</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1007/10_2007_089</idno><idno type="url">https://api-v5.istex.fr/document/16255347B412D2FD5DB45D7BC462DEFA1DACF753/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002273</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002273</idno><idno type="wicri:Area/Istex/Curation">002273</idno><idno type="wicri:Area/Istex/Checkpoint">000949</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000949</idno><idno type="wicri:doubleKey">0724-6145:2008:Pitre S:computational:methods:for</idno><idno type="wicri:Area/Main/Merge">002539</idno><idno type="wicri:Area/Main/Curation">002344</idno><idno type="wicri:Area/Main/Exploration">002344</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Computational Methods For Predicting Protein–Protein Interactions</title><author><name sortKey="Pitre, Sylvain" sort="Pitre, Sylvain" uniqKey="Pitre S" first="Sylvain" last="Pitre">Sylvain Pitre</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>School of Computer Science, Carleton University, 5304 Herzberg Building, 1125 Colonel By Drive, K1S 5B6, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Alamgir, Md" sort="Alamgir, Md" uniqKey="Alamgir M" first="Md" last="Alamgir">Md Alamgir</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biology and Ottawa Institute of Systems Biology, Carleton University, 209 Nesbitt Building, 1125 Colonel By Drive, K1S 5B6, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Green, James R" sort="Green, James R" uniqKey="Green J" first="James R." last="Green">James R. 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